Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

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Association between HLA genes and American cutaneous leishmaniasis in endemic regions of Southern Brazil

BACKGROUND The present study sought to investigate the association between HLA-A, HLA-B and HLA-DRB1 genes and susceptibility or resistance to the different clinical manifestations of American cutaneous leishmaniasis (ACL) in southern Brazil. METHODS The sample consisted of 169 patients with a diagnosis of ACL and 270 healthy subjects for comparison. HLA-A, HLA-B and HLA-DRB1 were typed by PC...

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Association between HLA-C*04 and American cutaneous leishmaniasis in endemic region of southern Brazil.

Leishmaniasis is a parasitic infectious disease with global repercussions. American cutaneous leishmaniasis (ACL) is endemic in southern Brazil and its pathogenesis varies according to parasite species, immune response, and host genetics. In terms of immunogenetics, many host genes, including HLA (human leukocyte antigen), could be involved in susceptibility to and protection against ACL. Accor...

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American cutaneous leishmaniasis in Brazil*

©2015 by Anais Brasileiros de Dermatologia Dear Editor, the case report on “American cutaneous leishmaniasis in Brazil” deals with an interesting topic.1 Bernardes Filho et al. reported on two new autochthonous cases of American cutaneous leishmaniasis in Brazil and state “the need for actions aiming at the early diagnosis and treatment of American cutaneous leishmaniasis cases.1” This report m...

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[Socioeconomic factors and attitudes towards household prevention of American cutaneous leishmaniasis in an endemic area in Southern Bahia, Brazil].

A survey was conducted to identify socioeconomic conditions and attitudes towards household prevention of American cutaneous leishmaniasis in Corte de Pedra, located in the county of Tancredo Neves, an endemic region in southern Bahia, Brazil. A questionnaire was applied in July 1997, focusing on social and economic variables, habits, and attitudes towards prevention of arthropod bites. All fam...

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Divergent Profile of Emerging Cutaneous Leishmaniasis in Subtropical Brazil: New Endemic Areas in the Southern Frontier

BACKGROUND Although known to be highly endemic in the Amazon regions of Brazil, the presence of cutaneous leishmaniasis (CL) in the subtropical southern part of the country has largely been ignored. This study was conducted to demonstrate CL is emerging in the Brazilian state of Santa Catarina, as well as to characterize the epidemiological profile and Leishmania species involved. METHODOLOGY...

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ژورنال

عنوان ژورنال: BMC Infectious Diseases

سال: 2013

ISSN: 1471-2334

DOI: 10.1186/1471-2334-13-198